Further evidence of the absence of measles virus genome sequence in full thickness intestinal specimens from patients with Crohn's disease

2000 ◽  
Vol 62 (3) ◽  
pp. 377-382 ◽  
Author(s):  
M.A. Afzal ◽  
E. Armitage ◽  
S. Ghosh ◽  
L.C. Williams ◽  
P.D. Minor
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Genome Sequence ◽  
Measles Virus ◽  
Virus Genome ◽  
Full Thickness

Searching for measles virus in Crohn's disease

1998 ◽  
Vol 114 ◽  
pp. A936-A937
Author(s):  
LAR Boerr ◽  
A Sambuelli ◽  
E. Baumeister ◽  
S Negreira ◽  
A Gil ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Measles Virus

Measles virus and Crohn's disease

The Lancet ◽  
1995 ◽  
Vol 345 (8954) ◽  
pp. 922-923 ◽  
Author(s):  
J. Hermon-Taylor ◽  
J. Ford ◽  
N. Sumar ◽  
D. Millar ◽  
T. Doran ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Measles Virus

Measles virus and Crohn’s disease

Gut ◽  
1999 ◽  
Vol 44 (6) ◽  
pp. 896.3-896
Author(s):  
M A AFZAL ◽  
P D MINOR ◽  
E ARMITAGE ◽  
S GHOSH
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Measles Virus

scholarly journals Measles virus serology in Crohn's disease.

Gut ◽  
1997 ◽  
Vol 41 (1) ◽  
pp. 66-69 ◽  
Author(s):  
N C Fisher ◽  
L Yee ◽  
P Nightingale ◽  
R McEwan ◽  
J A Gibson
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Measles Virus

Crohn's disease: Pathogenesis and persistent measles virus infection

1995 ◽  
Vol 108 (3) ◽  
pp. 911-916 ◽  
Author(s):  
Andrew J. Wakefield ◽  
Anders Ekbom ◽  
Amar P. Dhillon ◽  
R.Michael Pittilo ◽  
Roy E. Pounder
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Virus Infection ◽  
Measles Virus ◽  
Disease Pathogenesis

scholarly journals Granulomatous Vasculitis and Persistent Measles Virus Infection in Crohn’s Disease

1994 ◽  
Vol 8 (2) ◽  
pp. 70-74 ◽  
Author(s):  
AJ Wakefield
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Virus Infection ◽  
Cellular Immunity ◽  
Measles Virus ◽  
Recent Observation ◽  
Microvascular Endothelium ◽  
Granulomatous Vasculitis ◽  
Persistent Antigen

Based upon the recent observation of vasculitis in Crohn’s disease, a process that is more widespread than was recognized previously, the author investigated the possibility that this mechanism may provide an explanation for some of the clinical and histological idiosyncracies of this condition. In addition, it was suggested that the mesenteric microvascular endothelium may be a source of the persistent antigen that is responsible for ongoing cellular immunity in Crohn’s disease. This review discusses some of the studies designed to test these hypotheses, and discusses recent evidence for the presence of a measles-like virus in the endothelium in inflammatory foci, which may be relevant in the etiology of Crohn’s disease.

scholarly journals Crohn’s Disease – The Pathogenesis of a Granulomatous Vasculitis: A Hypothesis

1995 ◽  
Vol 9 (4) ◽  
pp. 199-202
Author(s):  
Andrew J Wakefield
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Measles Virus ◽  
Vascular Anatomy ◽  
Epidemiological Data ◽  
Microvascular Endothelium ◽  
Persistent Viral Infection ◽  
Granulomatous Vasculitis ◽  
Behavioural Characteristics ◽  
Traditional Approaches

Dissatisfied with traditional approaches to studying the pathogenesis of Crohn’s disease, the author and colleagues proposed and developed the hypothesis that Crohn’s disease is a granulomatous vasculitis mediated by a persistent viral infection of the mesenteric microvascular endothelium. Employing a range of techniques, the mesenteric vascular anatomy of intestine affected by Crohn’s disease was studied and the presence of a widespread multifocal vasculitis was demonstrated. Based upon certain behavioural characteristics of measles virus, including its tropism for intestinal endothelium and its ability to persist in human tissues, this agent was sought by in situ hybridization, electron microscopy and immunohistochemistry. The virus was detected in foci of granulomatous and lymphocytic inflammation. Recent epidemiological data from Sweden support the idea that early exposure to measles virus is a risk factor for the later development of Crohn’s disease. These data are consistent with the possibility of a persistent measles virus enteritis in the etiology and pathogenesis of Crohn’s disease and this hypothesis merits further study.

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